Asian Journal of Research in Chemistry

Jignesh P. Raval ¹, Hemul V. Patel ¹, Pradip S. Patel ¹, Nilesh H. Patel ¹, Kishor R. Desai ²

Affiliations
1 Department of Pharmaceutical Chemistry, Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences, New Vallabh Vidyanagar (Gujarat), IN
2 Department of Chemistry, Veer Narmad South Gujarat University, Udhna-Magdalla Road, Surat (Gujarat), IN

Abstract

We report efficient and extremely fast procedures for the synthesis of 3-chloro-4-(4-(diethylamino)-2-hydroxyphenyl)- 1-(substitutedphenyl)-azetidin-2-one using 4-diethylamino-2-hydroxybenzaldehyde, various amines and chloroacetyl chloride in presence of triethylamine under microwave irradiation (w) and similarly, conventional methods are used for comparison. A considerable increase in the reaction rate has been observed with better yield in microwave technique. The structures of the compounds were confirmed by elemental analysis and spectral analysis (1H-NMR, 13CNMR and Mass). All the compounds have been screened for their antifungal activity and their antibacterial activity against various gram +ve and gram –ve bacteria.

Keywords

4-Diethylamino-2-Hydroxybenzaldehyde, Azetidin-2-One, Microwave Method, Antimicrobial Activity.

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